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Antigenic Specificity | NCSTN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1 mg/mL |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternativ |
Immunogen | Immunogen: Recombinant protein of human NCSTN |
Other Names | [Anterior pharynx defective 2; APH 2; APH2; ATAG1874; KIAA0253; Ncstn; NCT; NICA; Nicastrin; RP11 517F10.1; RP11517F101] |
Gene, Accession # | [NCSTN], Gene ID: 23385, NCBI: NP_001277113.1, UniProt: Q92542 |
Catalog # | MBS2555391 |
Price | $150, $225, $360 |
Order / More Info | NCSTN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |