Description | CD271, also called LNGFR or p75NTR, is one of the two receptor types for the neurotrophins, a family of protein growth factors that stimulate neuronal cells to survive and differentiate. This family contains 4 proteins, NGF, BDNF, NT-3, NT-4. [1] It has shown that the LNGFR binds and serves as a sink for neurotrophins, cells expressing the LNGFR in the absence of Trk receptors may die rather than live in the presence of a neurotrophin.[2] |
Product Specific References | 1. Ip, N. Y., Stitt, T. N., Tapley, P., Klein, R., Glass, D. J., Fandl, J., Greene, L. A., Barbacid, M., Yancopoulos, G. D. Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron 10: 137-149, 1993. 2. Carter, B. D., Kaltschmidt, C., Kaltschmidt, B., Offenhauser, N., Bohm-Matthaei, R., Baeuerle, P. A., Barde, Y.-A. Selective activation of NF-kappa-B by nerve growth factor through the neurotrophin receptor p75. Science 272: 542-545, 1996. |