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Antigenic Specificity | Phospho-PP2A alpha (Y307) |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. |
Immunogen | Immunogen: A synthesized peptide derived from human Phospho-PP2A alpha (Y307) Subcellular Localization: Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity). |
Other Names | [Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; 3.1.3.16; Replication protein C; RP-C; PPP2CA] |
Gene, Accession # | [PPP2CA], Gene ID: 5515, NCBI: NP_002706.1, UniProt: P67775 |
Catalog # | MBS1750268 |
Price | $160, $340, $340 |
Order / More Info | Phospho-PP2A alpha (Y307) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |