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Antigenic Specificity | Phospho-MAPK14-pY322 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | p38 MAP kinase (MAPK), also called RK (1) or CSBP (2), is the mammalian orthologue of the yeast HOG kinase that participates in a signaling cascade controlling cellular responses to cytokines and stress (1-4). Four isoforms of p38 MAPK, p38alpha, beta, gamma (also known as Erk6 or SAPK3), and delta (also known as SAPK4) have been identified. Similar to the SAPK/JNK pathway, p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharide (LPS), UV light, and growth factors (1-5). MKK3, MKK6, and SEK activate p38 MAPK by phosphorylation at Thr180 and Tyr182. Activated p38 MAPK has been shown to phosphorylate and activate MAPKAP kinase 2 (3) and to phosphorylate the transcription fact |
Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding Y322 of human MAPK14 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15 SAPK2A; p38ALPHA] |
Gene, Accession # | [MAPK14-pY322], Gene ID: 1432, NCBI: NP_001306.1, UniProt: Q16539 |
Catalog # | MBS8527438 |
Price | $310 |
Order / More Info | Phospho-MAPK14-pY322 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Rouse, J. et al. (1994) Cell 78, 1027-1037. 2. Han, J. et al. (1994) Science 265, 808-811. 3. Lee, J.C. et al. (1994) Nature 372, 739-746. 4. Freshney, N.W. et al. (1994) Cell 78, 1039-1049. 5. Raingeaud, J. et al. (1995) J. Biol. Chem. 270, 7420-7426. 6. Zervos, A.S. et al. (1995) Proc. Natl. Acad. Sci. USA 92, 10531-10534. 7. Zhao, M. et al. (1999) Mol. Cell. Biol. 19, 21-30. 8. Yang, S.H. et al. (1999) Mol. Cell. Biol. 19, 4028-4038. 9. Cuenda, A. et al. (1995) FEBS Lett 364, 229-33. 10. Kumar, S. et al. (1999) Biochem Biophys Res Commun 263, 825-31. |