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Antigenic Specificity | FBL |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total FBL protein. Fibrillarin is a 2'-O-methyltransferase located in fibrillar regions and Cajal bodies of the nucleolus, where RNA transcription and pre-RNA processing take place (1,2). Fibrillarin associates with several other structual proteins as well as box C/D snoRNA to form a complex that functions in pre-rRNA processing, pre-rRNA methylation and ribosome assembly. This complex catalyzes site-specific 2'-O-ribose methylation of targeted nucleotides within the rRNA sequence (3,4). The sequence, structure and function of fibrillarin are highly conserved and fibrillarin gene expression is essential for early embryonic development (5). |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human FBL. |
Other Names | [FBL; FIB; FLRN; RNU3IP1] |
Gene, Accession # | [FBL], Gene ID: 2091, NCBI: NP_001427.2, UniProt: P22087 |
Catalog # | MBS9408856 |
Price | $255 |
Order / More Info | FBL Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |