Edit |   |
---|---|
Antigenic Specificity | NALP2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1b-processing activity and is thought to function as a modulator of NF-kB and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs). At least two alternatively spliced transcript variants |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a peptide corresponding to 12 amino acids near the carboxy terminus of human NALP2. |
Other Names | [NACHT domain-, leucine-rich-repeat-, and PYD-containing protein 2, PYRIN-containing APAF1-like protein2, PAN1, PYPAF2] |
Gene, Accession # | [NALP2], Gene ID: 55655, NCBI: NP_060322 |
Catalog # | MBS9411583 |
Price | $320 |
Order / More Info | NALP2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |