Description | Specificity: Chicken TCR gamma delta. MAb TCR1 precipitates a heterodimer of Mr 90-kDa (two bands of Mr 40-kDa and 50-kDa upon reduction) on chicken peripheral blood T cells.1,2 Deglycosylation of the heterodimer yields two polypeptides of Mr 35-kDa and 32-kDa from TCR1 precipitates. Unlike human and mouse, in which gamma delta cells comprise a minor subset of T lymphocytes in the circulation, the chicken has a relatively large subset of gamma delta T cells.1-3 The frequency of TCR gamma delta cells is usually 20-25% of the total blood T cells, but may reach approximately 50% in chickens of 6 months of age.2 The majority of TCR gamma delta + cells in the thymus and blood are CD4-CD8-, although a small subset of them may express CD8 or CD4 c |
Product Specific References | 1. Sowder, J.T., C.-L. Chen, L.L. Ager, M.M. Chan, and M.D. Cooper. 1988. J. Exp. Med. 167:315.2. Chen, C.H., J. Cihak, U. Losch, and M.D. Cooper. 1988. Eur. J. Immunol. 18:5393. Quere, P., M.D. Cooper, and G.J. Thorbecke. 1990. Immunology 71:517.4. Chen, C.H., T.W.F. Gobel, T. Kubota, and M.D. Cooper. 1993. 1994. Poultry Science 73:1012.5. Chen, C.-L. 1996. Personal communication.6. Sowder, J.T., C.H. Chen, L.L. Ager, J. Cihak, U. Losch, and M.D. Cooper. 1988b. Fed. Proc. 2:874.7. Cihak, J., U. Losch, G. Hoffman-Hezer, C.H. Chen, M.D. Cooper, and H.W.L. Ziegler-Heitbrock. 1993. Scand. J. Immunol. 38:123. |