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Antigenic Specificity | RAB7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: RAB7 antibody detects endogenous levels of total RAB7. Function: Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced p |
Immunogen | Immunogen: A synthesized peptide derived from human RAB7 Subcellular Location: Late endosome. Lysosome. Cytoplasmic Vesicle > Phagosome. Melanosome. Cytoplasmic Vesicle > Phagosome Membrane. Co-localizes with OSBPL1A at the late endosome. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium. Tissue Specificity: Widely expressed; high expression found in skeletal muscle. |
Other Names | [CMT2B; PRO2706; PSN; RAB7, member RAS oncogene family; RAB7A; RAB7A, member RAS oncogene family; RAB7A_HUMAN; Ras associated protein RAB7; Ras related protein Rab7; Ras related protein Rab7a; Ras-related protein Rab-7a] |
Gene, Accession # | [RAB7], Gene ID: 7879, NCBI: NP_004628.4, UniProt: P51149 |
Catalog # | MBS9608155 |
Price | $240, $280 |
Order / More Info | RAB7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |