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Antigenic Specificity | IGF1R (Phospho-Tyr1346) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of IGF1R only when phosphorylated at tyrosine 1346. This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.Ullrich A., EMBO J. 5:2503-2512(1986).Abbot A.M., J. Biol. Chem. 267:10759-10763(1992).The MGC Project Team;Genome Res. 14:2121-2127(2004). |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of tyrosine 1346(Q-P-Y(p)-A-H) derived from Human IGF1R. |
Other Names | [CD221; kinase IGF1R; IGF1R] |
Gene, Accession # | [IGF1R], Gene ID: 3480, NCBI: NP_000866.1, UniProt: P08069 |
Catalog # | MBS9406331 |
Price | $200, $255 |
Order / More Info | IGF1R (Phospho-Tyr1346) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |