Bax (A20) Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Bax (A20) antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | Bax (A20) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat, human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.2 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Bcl-2 family of proteins is a key regulator of apoptosis that function to either inhibit or promote cell death. The over expression of members such as Bcl-2 and Bcl-xL inhibit the apoptotic process (1,2). The Bcl-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag-1, for example, has been found to form a heterodimer with Bcl-2 resulting in the enhancement of the anti-apoptotic effect of Bcl-2 (3,4). Other anti-apoptotic Bcl-2 family members include A1, Bcl-xg, Bcl-xb, Mcl-1, BAR, BI-1 and Bcl-w (5). The pro-apoptotic family members include Bax, Bcl-xS, Bad, Bak, NBK, BID, Hrk, Bok, Bim, Noxa and Diva. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus i |
| Immunogen | n/a |
| Other Names | [bax, partial; Apoptosis regulator BAX; apoptosis regulator BAX; Bcl2-associated X protein], [Bax; Bax] |
| Gene, Accession # | [Bax], Gene ID: 24887, NCBI: AAA75200.1, UniProt: Q63690 |
| Catalog # | MBS440005 |
| Price | $240 |
| Order / More Info | Bax (A20) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1.) You WK, Seo HJ, Chung KH, Kim DS. 2003. A novel metalloprotease from Gloydius halys venom induces endothelial cell apoptosis through its protease and disintegrin-like domains. J Biochem (Tokyo) Nov;134(5):739-49. 2.) Kim J, Seong J, and Kim SH. 2004. Enhancement of Tumor Response by Farnesyltransferase Inhibitor in C3H/HeJ Hepatocarcinoma. Ann N Y Acad Sci. Dec;1030:95-102. 3.) Ma D, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze M. 2005. Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ann Neurol. Aug;58(2):182-93.4.) Wan Y, Xu J, Ma D, Zeng Y, Cibelli M, Maze M. 2007. Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology. Mar;106(3):436-43.1. Huang Z. 2000. Bcl-2 family proteins as targets for anticancer drug design. Oncogene 19(56): 6627-66312. Reed JC. 1997. Double identity for proteins of the Bcl-2 family. Nature 387(6635): 773-7763. Eversole-Cire P, Concepcion FA, Simon MI, Takayama S, Reed JC, Chen J. 2000. Synergistic effect of Bcl-2 and BAG-1 on the prevention of photoreceptor cell death. Invest Ophthalmol Vis Sci 41(7): 1953-19614. Coldwell MJ, deSchoolmeester ML, Fraser GA, Pickering BM, Packham G, Willis AE. 2001. The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock. Oncogene 20(30): 4095-41005. Bae j, Hsu SY, Leo CP, Zell K, Hsueh AJ. 2001. Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis. Apoptosis 6(5): 319-3306. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ. 2001. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292(5517): 624-6267. Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ. 1995. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80(2): 285-2918. Fridman JS, Parsels J, Rehemtulla A, Maybaum J. 2001. Cytochrome c depletion upon expression of Bcl-XS. J Biol Chem 276(6): 4205-109. Lindenboim L, Yuan J, Stein R. 2000. Bcl-xS and Bax induce different apoptotic pathways in PC12 cells. Oncogene 19(14): 1783-1793 |
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MYBIOSOURCE INC.
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