Edit |   |
---|---|
Antigenic Specificity | THEM4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4. THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondria |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against an 18 amino acid peptide near the center of human THEM4. |
Other Names | [Thioesterase superfamily member 4, Carboxy-terminal modulator protein, CTMP] |
Gene, Accession # | [THEM4], Gene ID: 117145, NCBI: NP_444283 |
Catalog # | MBS9409381 |
Price | $320 |
Order / More Info | THEM4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |