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Antigenic Specificity | ITGAM |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell dev |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-330 of human ITGAM (NP 001139280.1). |
Other Names | [CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6] |
Gene, Accession # | [ITGAM], Gene ID: 3684, NCBI: NP_001139280.1, UniProt: P11215 |
Catalog # | MBS8544458 |
Price | $280 |
Order / More Info | ITGAM Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |