Description | Specificity: KLRG1 (Mr 30-38 kDa). The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA or 2F1-Ag), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains.1, 2 These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1.3, 4 The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL).1, 5 Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirec |
Product Specific References | 1. Corral, L., T. Hanke, R.E. Vance, D. Cado, and D.H. Raulet. 2000. Eur. J. Immunol. 30:920.2. Hanke, T., L. Corral, R.E., Vance, and D.H. Raulet. 1998. 28:4409.3. Burshtyn, D., A. Scharenberg, N. Wagtmann, S. Rajagopalan, M. Peruzzi, J.-P. Kinet, and E.O. Long. 1997. Immunity 4:77.4. Nakamura, M.C., E.C. Niemi, M.J. Fisher, L.D. Schultz, W.E. Seaman, and J.C. Ryan. 1997. J. Exp. Med. 185:673.5. Liu, S., and D.H. Raulet. Personal communication. |