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Antigenic Specificity | SFPQ (578) |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG |
Format | unconjugated |
Size | 0.02 mL, 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | DNA and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in a spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatory elements which represses exon inclusion. |
Immunogen | Host Note: This monoclonal antibody is produced by immunizing mice with a polypeptide corresponding to SFPQ protein. |
Other Names | [PPP1R140, PSF], [SFPQ; SFPQ; PSF; POMP100; PPP1R140; PSF; PSF1 |
Gene, Accession # | [SFPQ], Gene ID: 6421, NCBI: NP_005057.1, UniProt: P23246 |
Catalog # | MBS435103 |
Price | $225, $350, $565 |
Order / More Info | SFPQ (578) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |