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Antigenic Specificity | CD253/TRAIL (IN2) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes ~~34 kDa of human TRAIL protein. The TRAIL (TNF related apoptosis induced ligand) or Apo 2L /CD253 protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. The ligand binding to its receptors DR4/DR5 initiates apoptosis of tumor cells. TRAIL is expressed predominantly in spleen, lung, and prostate but also in many other tissues. TRAIL is a type II membrane protein from the TNF family. The human form of the protein is 281 amino acids in length, whereas the murine form is 291 amino acids. The two forms share 65% identity. TRAIL protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | [CD253/TRAIL], Gene ID: 8743 |
Catalog # | MBS460361 |
Price | $270 |
Order / More Info | CD253/TRAIL (IN2) Antibody from MYBIOSOURCE INC. |
Product Specific References | Pitti, R.M., Marsters, S.A., Ruppert, S., Donahue, C.J., Moore, A. and Ashkenazi, A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271 (22), 12687-12690 (1996) |