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Antigenic Specificity | Phospho-RanBP3 (Ser126/58) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-RanBP3 (Ser126/58) antibody detects endogenous levels of RanBP3. Function: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.Subunit Structure: Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1. Interacts (via i |
Immunogen | Immunogen: A synthesized peptide derived from human RanBP3 around the phosphorylation site of Ser126/58. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Widely expressed with high levels in testis and heart. |
Other Names | [DKFZp586I1520; Ran binding protein 3; Ran-binding protein 3; RANB3_HUMAN; RanBP3] |
Gene, Accession # | [RanBP3], Gene ID: 8498, NCBI: NP_001287794.1, UniProt: Q9H6Z4 |
Catalog # | MBS9600722 |
Price | $240, $280 |
Order / More Info | Phospho-RanBP3 (Ser126/58) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |