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Antigenic Specificity | CHP2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total CHP2 protein. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.Loftus B.J., Genomics 60:295-308(1999).Wang Y., J. Immunol. 169:1102-1109(2002).Pang T., J. Biol. Chem. 277:43771-43777(2002). |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of humanCHP2. |
Other Names | [Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520; CHP2; HCA520] |
Gene, Accession # | [CHP2], Gene ID: 63928, NCBI: NP_071380.1, UniProt: O43745 |
Catalog # | MBS9411175 |
Price | $200, $255 |
Order / More Info | CHP2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |