Bcl-2 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Bcl-2 antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | Bcl-2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Bcl-2 exerts a survival function in response to a wide range of apoptotic stimuli through inhibition of mitochondrial cytochrome c release (1). It has been implicated in modulating mitochondrial calcium homeostasis and proton flux (2). Several phosphorylation sites have been identified within Bcl-2 including Thr56, Ser70, Thr74 and Ser87 (3). It has been suggested that these phosphorylation sites may be targets of the ASK1/MKK7/JNK1 pathway, and that phosphorylation of Bcl-2 may be a marker for mitotic events (4,5). Mutation of Bcl-2 at Thr56 or Ser87 inhibits its antiapoptotic activity during glucocorticoidinduced apoptosis of T lymphocytes (6). Interleukin 3 and JNKinduced Bcl2 phosphorylation at Ser70 may be required for its enhanced ant |
| Immunogen | Immunogen: Fusion protein of human Bcl-2 |
| Other Names | [BCL2; Bcl-2; BCL2; Bcl2; ONCOGENE BCELL LEUKEMIA 2; Apoptosis regulator Bcl2], [BCL2; BCL2; Bcl-2; PPP1R50] |
| Gene, Accession # | Gene ID: 596, NCBI: NP_000624.2, UniProt: P10415 |
| Catalog # | MBS126612 |
| Price | $235, $350 |
| Order / More Info | Bcl-2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Murphy, K.M. et al. (2000) Cell Death Differ 7, 102-11. 2. Zhu, L. et al. (1999) J Biol Chem 274, 33267-73. 3. Maundrell, K. et al. (1997) J Biol Chem 272, 25238-42. 4. Yamamoto, K. et al. (1999) Mol Cell Biol 19, 8469-78. 5. Ling, Y.H. et al. (1998) J Biol Chem 273, 18984-91. 6. Huang, S.T. and Cidlowski, J.A. (2002) FASEB J 16, 825-32. 7. Deng, X. et al. (2001) J Biol Chem 276, 23681-8. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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