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Antigenic Specificity | HAX-1, Human |
Clone | AT3C5 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b kappa |
Format | Protein G purified |
Size | 50ul, 100ul |
Concentration | 1mg/ml (determined by BCA assay) |
Applications | ELISA,WB,ICC/IF |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1 (HS1), one of the substrates of receptor-coupled tyrosine kinases activated during clonal expansion and deletion in lymphoid cells. It also interacts with the product of the polycystic kidney disease 2 (PKD2) gene and with the F-actin-binding protein, cortactin. HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, so may play a role in mRNA stability and transport. It may also function in promoting cell survival. Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease. |
Immunogen | Recombinant human HAX1 (1-279aa) purified from E. coli |
Other Names | HCLS1 associated protein X-1, HS1BP1, HCLSBP1, HCLS1 (and PKD2) associated protein |
Gene, Accession # | NCBI: NP_006109, UniProt: O00165 |
Catalog # | ATGA0156 |
Price | $170, $290 |
Order / More Info | HAX-1, Human Antibody from NKMAX Co. Ltd. |
Product Specific References | n/a |