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Antigenic Specificity | AIF/AIFM1, Human |
Clone | AT22E9 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a kappa |
Format | Protein A purified |
Size | 50ul, 100ul |
Concentration | 1mg/ml (determined by BCA assay) |
Applications | ELISA, WB, ICC/IF |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Apoptosis-inducing factor 1, also known as AIFM1, is a mitochondrial protein that translocates to the nucleus upon induction of apoptosis. AIFM1 has been shown to cause DNA fragmentation and chromatin condensation and to induce the release of cytochrome c and caspase-9 from mitochondria. Bcl-2 overexpression has been shown to prevent the release of AIFM1 from mitochondria, but not to block its apoptogenic activity. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. |
Immunogen | Recombinant human AIFM1 (98-609aa) purified from E. coli |
Other Names | Apoptosis-inducing factor 1 mitochondrial isoform 2 precursor, AIF, CMTX4, COWCK, COXPD6, PDCD8 |
Gene, Accession # | NCBI: NP_665811, UniProt: O95831 |
Catalog # | ATGA0411 |
Price | $170, $290 |
Order / More Info | AIF/AIFM1, Human Antibody from NKMAX Co. Ltd. |
Product Specific References | n/a |