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Antigenic Specificity | MERS-CoV Spike |
Clone | AT6E6 |
Host Species | Mouse |
Reactive Species | MERS-CoV |
Isotype | IgG1 kappa |
Format | Protein A purified |
Size | 50ul, 100ul |
Concentration | 1mg/ml (determined by BCA assay) |
Applications | ELISA |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MERS Spike Antibody (1ug/ml) specifically recognizes MERS Spike and Spike S1 recombinant protein, but not interacted MERS Spike S2 and RBD recombinant protein in ELISA.. MERS-CoV, which causes the Middles East Respiratory Syndrome (MERS), belongs to a family of viruses known as coronaviruses. MERS-CoV was first identified in the Kingdom of Saudi Arabia in 2012, which is a single and positive stranded RNA virus. Dromedary camels are widely considered as the source of the transmission of MERS-CoV. The rate of human transmission among household contacts of MERS patients has been approximately 5 % based on serological analysis. MERS-CoV has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The spike protein, responsible for allowing the virus to attach to and fuse with the membrane of a host cell and is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. MERS-CoV S mediates viral attachment and fusion to human cells via human cellular receptor DPP4, also known as CD26. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. |
Immunogen | Recombinant MERS-CoV Spike (18-1296aa) purified from Baculovirus |
Other Names | Middle East respiratory syndrome coronavirus, Human betacoronavirus 2c EMC/2012, MERS-CoV, MERS, MERSCoV SP, Spike glycoprotein, S glycoprotein, S, Spike protein |
Gene, Accession # | NCBI: AFS88936, UniProt: K0BRG7 |
Catalog # | ATGA0598 |
Price | $170, $290 |
Order / More Info | MERS-CoV Spike Antibody from NKMAX Co. Ltd. |
Product Specific References | Lee K, et al. Development of a diagnostic system for detection of specific antibodies and antigens against Middle East respiratory syndrome coronavirus. (Microbiol Immunol. 2018){https://pubmed.ncbi.nlm.nih.gov/30117617/};;Goo J, et al. Characterization of novel monoclonal antibodies against MERS-coronavirus spike protein. (Virus Res. 2020){https://pubmed.ncbi.nlm.nih.gov/31945421/} |