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Antigenic Specificity | GCLM, Human |
Clone | AT2D12 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 kappa |
Format | Protein G purified |
Size | 50ul, 100ul |
Concentration | 1mg/ml (determined by BCA assay) |
Applications | ELISA,WB,ICC/IF |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | GCLM (Glutamate-cysteine ligase, modifier subunit), also known as gamma-glutamylcysteine synthetase, is first rate limiting enzyme of glutathione synthesis. GCLM is heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. GCLM deficiency has been implicated in some forms of hemolytic anemia. Also, GCLM is a molecular target for amelioration of cisplatin restance in lung cancer. |
Immunogen | Recombinant human GCLM (1-274aa) purified from E. coli |
Other Names | Glutamate-cysteine ligase modifier subunit, Glutamate-cysteine ligase, modifier subunit, GLCLR |
Gene, Accession # | NCBI: NP_002052, UniProt: P48507 |
Catalog # | ATGA0229 |
Price | $170, $290 |
Order / More Info | GCLM, Human Antibody from NKMAX Co. Ltd. |
Product Specific References | n/a |