ADAM10 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | ADAM10 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | IgG fraction |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | ADAM10 IgG fraction antibody is directed against human ADAM10 protein. The product is affinity chromatography purified via peptide column. A BLAST analysis was used to suggest cross-reactivity with ADAM10 protein from human, bovine and rat based on 100% homology with the immunizing sequence. Partial reactivity is expected against ADAM10 from mouse based on a single amino acid change relative to this sequence. Reactivity against homologues from other sources is not known. Proinflammatory cytokine tumor necrosis factor-α (TNF-α) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-α, notch, and its ligand delta, are all membrane-bound molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-α, notch and its ligand delta. The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ) and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues. Anti-ADAM10 is ideal for investigators involved in NF-kappaB, Apoptosis, Cytokins and Growth factor research. |
| Immunogen | This IgG fraction antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminus of human ADAM10 protein. |
| Other Names | A disintegrin and metalloprotease domain 10 antibody, A Disintegrin And Metalloproteinase Domain 10 antibody, ADAM 10 antibody, ADAM metallopeptidase domain 10 antibody, CD 156c antibody, KUZ, MADM |
| Gene, Accession # | ADAM10, Gene ID: 102, NCBI: 4557251, UniProt: O14672 |
| Catalog # | 200-401-949 |
| Price | $475 |
| Order / More Info | ADAM10 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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