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Antigenic Specificity | Nhe-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Nhe-1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Nhe-1 from other sources has not been determined. The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension. At least two isoforms of Nhe-1 are known to exist. |
Immunogen | Anti-Nhe-1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide near the internal region of the human Nhe-1. |
Other Names | Nhe-1 Antibody, APNH, NHE1, NHE-1, APNH1, APNH |
Gene, Accession # | SLC9A1, Gene ID: 6548, NCBI: P19634, UniProt: P19634 |
Catalog # | 600-401-DA8 |
Price | $475 |
Order / More Info | Nhe-1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |