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Antigenic Specificity | ADORA2B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-ADORA2B antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. ADORA2B antibody is human, mouse and rat reactive. At least two isoforms of ADORA2B are known to exist; this antibody will detect both isoforms. ADORA2B antibody is predicted to not cross-react with ADORA2A. The adenosine receptor ADORA2B is a member of the G protein-coupled receptor superfamily and is an integral membrane protein that stimulates adenylate cyclase activity in the presence of adenosine (1,2). Extracellular adenosine triggers a potent anti-inflammatory response that is mediated in part by ADORA2B including the stimulation of IL-10 production (3-5). Activation of ADORA2B can also enhance the abundance of regulatory T cells (Tregs), a class of cells that work to constrain inflammation (6). |
Immunogen | Anti-ADORA2B antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid peptide near the C-terminus of human ADORA2B. The immunogen is located within the last 50 amino acids of ADORA2B. |
Other Names | Adenosine receptor A2b, ADORA2 |
Gene, Accession # | ADORA2B, Gene ID: 136, NCBI: NP_000667, UniProt: P29275 |
Catalog # | 600-401-X73 |
Price | $475 |
Order / More Info | ADORA2B Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |