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Antigenic Specificity | B-raf |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-B-raf Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least two isoforms of B-raf are known to exist; this antibody will detect both isoforms. This antibody will not cross-react with C-raf. Predicted species reactivity based on immunogen sequence: Rat: (100%), Chicken: (100%). B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. The Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt pathways interact with each other to regulate growth and in some cases tumorigenesis. Mutations in B-raf have been associated with several cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung, leading to speculation on the possibility of B-raf as a therapeutic target for treating cancers. Mutations in this gene have also been associated with cardiofaciocutaneous syndrome (CFCS), a disease characterized by heart defects, mental retardation and a distinctive facial appearance. |
Immunogen | Anti-B-raf antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid peptide near the internal region of human B-raf. The immunogen is located within amino acids 330 - 380 of B-raf. |
Other Names | B-raf Antibody, NS7, BRAF1, RAFB1, B-RAF1, Proto-oncogene B-Raf |
Gene, Accession # | BRAF, Gene ID: 673, NCBI: NP_004324.2, UniProt: P15056 |
Catalog # | 600-401-Z87 |
Price | $475 |
Order / More Info | B-raf Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |