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Antigenic Specificity | Slitrk1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Slitrk1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody is predicted to have no cross-reactivity to other Slitrk proteins. SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all. |
Immunogen | Anti-Slitrk1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 18 amino acid synthetic peptide from near the internal region of human Slitrk1. |
Other Names | Slitrk1 Antibody, TTM, LRRC12, KIAA1910, UNQ233/PRO266, SLIT and NTRK-like protein 1, Leucine-rich repeat-containing protein 12 |
Gene, Accession # | SLITRK1, Gene ID: 114798, NCBI: NP_443142, UniProt: Q96PX8 |
Catalog # | 600-401-EQ0 |
Price | $475 |
Order / More Info | Slitrk1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |