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Antigenic Specificity | APP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1.0 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-APP Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with APP from other sources has not been determined. Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the brains of all suffers of Alzheimer's disease. |
Immunogen | Anti-APP antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid peptide near the C-terminus of human APP. |
Other Names | APP Antibody, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma, A4, Amyloid beta A4 protein, APP |
Gene, Accession # | APP, Gene ID: 351, NCBI: CAA30050, UniProt: P05067 |
Catalog # | 600-401-Y49 |
Price | $475 |
Order / More Info | APP Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |