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Antigenic Specificity | Adenovirus-9 E4 Orf1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Adenovirus-9 E4 Orf1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Adenovirus-9 E4 Orf1 from other sources has not been determined. The many different serotypes of human adenoviruses (Ad) are divided into six subgroups, of which all Ad subgroup A and B and two subgroup D Ads can elicit tumors in infected rodents. Unlike the Ads from subgroup A and B, the ones from subgroup D, Ad9 and Ad10 elicit estrogen-dependent mammary tumors as opposed to undifferentiated sarcomas. In the case of Ad9, its tumorigenicity is dependent on the product of the open reading frame (ORF) 1 of the early region 4 (E4). The tumorigenic potential of Ad9 E4 Orf1 depends on a carboxyl-terminal PDZ domain-binding motif that mediates interactions with several different membrane-associated cellular proteins such as MUPP1, PATJ, MAGI-1, ZO-2 and Dlg1. It has been suggested that Ad9 E4 Orf1 may have evolved from an ancestral cellular dUTP pyrophosphatase. |
Immunogen | Anti-Ad-9 E4 Orf1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide near the C-terminus of the Ad-9 E4 Orf1. |
Other Names | Adenovirus-9 E4 Orf1 Antibody, E4-ORF1, ORF1 |
Gene, Accession # | E4 UniProt: P89079 |
Catalog # | 600-401-X72 |
Price | $475 |
Order / More Info | Adenovirus-9 E4 Orf1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |