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Antigenic Specificity | AIF |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-AIF Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with AIF from other sources has not been determined. Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection. AIF is highly conserved between human and mouse and widely expressed. |
Immunogen | Anti-AIF antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid peptide near the C-terminus of human AIF. |
Other Names | AIF Antibody, AIFM1, PDCD8, Apoptosis-inducing factor 1 |
Gene, Accession # | AIFM1, Gene ID: 9131, NCBI: NP_001124318.2, UniProt: O95381 |
Catalog # | 600-401-X84 |
Price | $475 |
Order / More Info | AIF Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |