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Antigenic Specificity | IKB alpha |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | serum |
Size | 100 µL |
Concentration | 80 mg/mL |
Applications | ELISA, Immunohistochemistry, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | IKB alpha Antibody was prepared from monospecific antiserum by delipidation and defibrination. Anti- IkBa may react non-specifically with other proteins. Control peptide (code #100-4167P) will compete only with the specific reaction of antiserum with IkBa. Anti-IKB alpha Antibody detects IkBa. I-kappa-B-alpha inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, IKBA becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. Anti-IKBa Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction and Immunology research. |
Immunogen | IKB alpha Antibody was produced by repeated immunizations with a synthetic IkBa peptide corresponding to a region near the C-terminus of the human protein. |
Other Names | rabbit anti-IKB alpha Antibody, IkappaBalpha antibody, IKBA antibody, IKBalpha antibody, MAD3 antibody, NF kappa B inhibitor alpha antibody, NFKBI antibody, NFKBIA antibody |
Gene, Accession # | NFKBIA, Gene ID: 4792, NCBI: CAB65556.2, UniProt: P25963 |
Catalog # | 100-4167C |
Price | $475 |
Order / More Info | IKB alpha Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | PubMed: 9343439 // 9566902 // 9988719 // 12648451 |