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Antigenic Specificity | gp120 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1.0 mg/ml |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-gp120 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with gp120 from other sources has not been determined. Human immunodeficiency virus type 1 (HIV-1) entry into target cells is directed by the envelope (Env) glycoproteins, which are present on the surface of HIV-1 virion or infected cells in the form of trimers consisting of gp120/gp41 complexes. The surface subunit, gp120, initiates the entry process by interacting sequentially with the CD4 receptor and a co-receptor CCR5 or CXCR4, thereby inducing a conformational change that allows the transmembrane (TM) gp41 subunit to mediate fusion between viral and target cell membranes. Cleavage of Env into its gp120 and gp41 components is necessary for activation of its fusogenic activity. |
Immunogen | Anti-gp120 antibody was prepared from whole rabbit serum produced by repeated immunizations with 16 amino acid synthetic peptide representing the major HIV-1 consensus sequence near the N-terminal region of V1/V2 loop. |
Other Names | gp120 Antibody, Envelope glycoprotein gp160 |
Gene, Accession # | env, Gene ID: 155971, NCBI: AAT67551, UniProt: Q6BBS3 |
Catalog # | 600-401-BM6 |
Price | $475 |
Order / More Info | gp120 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |