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Antigenic Specificity | Llama IgG2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | llama |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.5 mg |
Concentration | 1.07 mg/ml |
Applications | ELISA, Immunohistochemistry, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Llama IgG2 antibody is directed against Llama IgG2 with minimal cross-reactivity to Llama IgG3 and Llama IgG1. Anti-Llama IgG2 antibody was prepared from monospecific antiserum by immunoaffinity chromatography. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-rabbit serum, Llama IgG2 and Llama Serum. Specificity was confirmed by ELISA. For IgG1 and IgG3 reactivity was less than 5% against target (IgG2). This antibody does not recognize recombinant VHH with IgG3 background. Camelids produce functional IgG isotypes that do not incorporate light chains. Comparative studies of old world camelids (Camelus bactrianus and Camelus dromedarius) and new world camelids (Lama pacos, Lama glama and Lama vicugna) have shown that heavy-chain-only immunoglobulins represent between 35% - 70% of total IgG in the sera of all species. At present, three subclasses of camelid IgG have been identified (IgG1, IgG2, IgG3), of which IgG2 and IgG3 lack the light chains. IgG2 consists of dimers of short heavy chains, which are characterized by a normal Fc region without a CH1 domain. IgG2 shows a molecular weight of approximately 90 kDa and this smaller size improves its bio-distribution and allows a better tissue penetration. Of special importance is the long complementary determining region (CDR) loop which inserts deep into the active site of an enzyme enabling a complete neutralization of an enzyme. Anti-Llama IgG2 generated in rabbit detects specifically Llama IgG2 isotype. This anti-Llama secondary Antibody is suitable for western blot, ELISA, ChIP and immunohistochemistry as well as other more general immunoassays. |
Immunogen | Llama IgG2 |
Other Names | IgG2 antibody, Llama IgG2, anti-subclass secondary antibody |
Gene, Accession # | n/a |
Catalog # | 634-401-044 |
Price | $199 |
Order / More Info | Llama IgG2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |