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Antigenic Specificity | BACE2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | Immunohistochemistry, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-BACE2 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with BACE2 with Human, Mouse and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with BACE2 from other sources has not been determined. BACE2 antibody detects human amyloid-beta (Abeta) plaque. Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called `Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome. Anti-BACE2 antibodies are ideal for investigators involved in Neuroscience and DNA Damage and Repair. |
Immunogen | BACE2 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to an internal region of human BACE2. |
Other Names | AEPLC, ALP56, ASP21 |
Gene, Accession # | BACE2, Gene ID: 25825, NCBI: NP_036237.2, UniProt: Q9Y5Z0 |
Catalog # | 600-401-G82 |
Price | $475 |
Order / More Info | BACE2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |