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Antigenic Specificity | BECLIN1 phospho S234 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunoaffinity purified, no preservative |
Size | 100 µL |
Concentration | n/a |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Beclin1 pS234 Antibody is directed against Beclin 1 protein phosphorylated at S234. The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. This antibody is specific for phosphorylated beclin1. Minimal reactivity occurs against non-phosphorylated beclin1. Reactivity against Beclin 1 occurs from human sources. However, reactivity is also expected against bovine, canine, mouse, non-human primate, rat, and sheep. Beclin-1 plays a key role in tumor suppression and autophagy. It has been suggested that autophagy proteins such as beclin-1 can inhibit tumorigenesis and that decreased expression of these proteins may contribute to the development of human malignancies. Beclin-1 has been shown to interact with 14-3-3 proteins through Akt-mediated phosphorylation at Ser234. Beclin 1 pS234 Antibody is ideal for researchers interested in cancer research. |
Immunogen | Anti-Phospho-Ser234 Beclin-1 Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser234 of human Beclin-1 conjugated to KLH. |
Other Names | Run domain Beclin-1 interacting and cysteine-rich containing protein, Rubicon, Beclin-1 associated RUN domain containing protein |
Gene, Accession # | BECN1, Gene ID: 8678, NCBI: NP_001300927.1, UniProt: Q14457 |
Catalog # | 600-401-W96 |
Price | $475 |
Order / More Info | BECLIN1 phospho S234 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | PubMed: 28253954 |