GABA(A) Receptor gamma 2 phospho S327 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | GABA(A) Receptor gamma 2 phospho S327 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-GABA(A) Receptor gamma 2 pS327 Antibody is directed against rat phosphorylated GABA(A) Receptor gamma 2. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling of the GABAA band is completely blocked by lambda-phosphatase treatment. This antibody is directed against rat GABA(A) receptor gamma 2 proteins phosphorylated at Ser327. Cross reactivity with GABA(A) Receptor gamma 2 pS327 from other sources has not been determined. However, reactivity is also expected against bovine, canine, chicken, human, and non-human primate. Anti-GABA(A) Receptor gamma 2 pS327 Antibody detects phosphorylated GABA(A) Receptor gamma 2. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma- subunit is required for benzodiazepine modulation. It has recently been suggested that PKC? regulates the sensitivity of GABAA alpha1-beta2-gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2. GABA(A) Receptor gamma2 pS327 antibody is ideal for investigators involved in Neuroscience. |
| Immunogen | Anti-GABA(A) Receptor gamma 2 pS327 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser327 of rat GABAA receptor gamma 2. |
| Other Names | Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, Gabrg2 |
| Gene, Accession # | Gabrg2, Gene ID: 29709, NCBI: 8393403, UniProt: P18508 |
| Catalog # | 612-401-D52 |
| Price | $475 |
| Order / More Info | GABA(A) Receptor gamma 2 phospho S327 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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