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Antigenic Specificity | Synapsin I phospho S549 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µL |
Concentration | n/a |
Applications | Immunohistochemistry, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Synapsin I pS549 antibody is directed against rat Synapsin I. Synapsin I pS549 was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling of the synapsin I band is blocked by lambda-phosphatase treatment. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, human, mouse, and non-human primate. Synapsin I pS549 antibody is directed against rat Synapsin I, which plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation. Ser 549 along with Ser 62 and Ser 67 are the sites of synapsin I that are phosphorylated by MAP kinase. Phosphorylation and subsequent dephosphorylation of this site is thought to play a key role in synaptic vesicle trafficking. Anti-Synapsin I pS549 Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research. |
Immunogen | Anti-Synapsin I pS549 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser549 of Synapsin I. |
Other Names | Synapsin I, SYN1, Synapsin-1 |
Gene, Accession # | Syn1, Gene ID: 24949, NCBI: NP_001104252.1, UniProt: P09951 |
Catalog # | 612-401-C94 |
Price | $475 |
Order / More Info | Synapsin I phospho S549 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |