CD11c Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | CD11c |
| Clone | 3.9 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | fluorescein (FITC) conjugate |
| Size | 500 µL |
| Concentration | n/a |
| Applications | Flow Cytometry, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Fluorescein conjugated CD11c Monoclonal Antibody was purified from tissue culture supernatant via affinity chromatography and is directed against human CD11c. Reactivity is observed against human CD11c, Chimpanzee, Baboon, African Green, Cynomolgus, Rhesus, and Squirrel Monkey. Cross reactivity with CD11c from other sources has not been tested. Anti-CD11c is conjugated with FITC under optimal conditions and the solution is free of unconjugated FITC. CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αX and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CT. The 3.9 antibody reacts with human CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells. |
| Immunogen | Anti-CD11c Antibody (Monoclonal) was produced by repeated immunizations with CD11c antigen. |
| Other Names | Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150 95, CD11c |
| Gene, Accession # | ITGAX, Gene ID: 3687, NCBI: NP_000878.2, UniProt: P20702 |
| Catalog # | 200-302-N63 |
| Price | $325 |
| Order / More Info | CD11c Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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