ZBRK1 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | ZBRK1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-ZBRK1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with ZBRK1 from other sources has not been determined. ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions. |
| Immunogen | Anti-ZBRK1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 20 amino acid synthetic peptide near the C-terminus of the human ZBRK1. |
| Other Names | ZBRK1 Antibody, ZFQR, ZBRK1, Zinc finger protein 350, KRAB zinc finger protein ZFQR |
| Gene, Accession # | ZNF350, Gene ID: 59348, NCBI: NP_067645.3, UniProt: Q9GZX5 |
| Catalog # | 600-401-GB3 |
| Price | $475 |
| Order / More Info | ZBRK1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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