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Antigenic Specificity | PHAP I |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-PHAP I Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III. Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation. |
Immunogen | Anti-PHAP I antibody was raised with a synthetic peptide corresponding to amino acids close to C-terminus of human PHAP I. This sequence is identical between human and rat PHAP I. |
Other Names | PHAP I Antibody, LANP, MAPM, PP32, HPPCn, PHAP1, PHAPI, I1PP2A, C15orf1, LANP, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32 |
Gene, Accession # | ANP32A, Gene ID: 8125, NCBI: P39687, UniProt: P39687 |
Catalog # | 600-401-DL7 |
Price | $475 |
Order / More Info | PHAP I Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |