NMDA R2B phospho S1480 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | NMDA R2B phospho S1480 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µL |
| Concentration | n/a |
| Applications | Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-NMDA R2B pS1480 antibody is directed against phosphorylated NMDA receptor protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. The antibody is specific for NMDA receptor phosphorylated at S1480. Immunolabeling is blocked by lambda-phosphatase treatment. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, chicken, human, mouse, non-human primates and Xenopus. NMDA R2B pS1480 antibody detects rat NMDA 2B receptor protein. The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. It has been shown that phosphorylation of Ser1480 disrupts the interaction of NR2B with the PDZ domains of PSD-95 and SAP102 and decreases surface NR2B expression in neurons. Anti-NMDA R2B pS1480 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, and Signal Transduction research. |
| Immunogen | Anti-NMDA R2B pS1480 Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1480. |
| Other Names | Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, Grin2b, NR3 |
| Gene, Accession # | Grin2b, Gene ID: 24410, UniProt: Q00960 |
| Catalog # | 612-401-D93 |
| Price | $475 |
| Order / More Info | NMDA R2B phospho S1480 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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