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Antigenic Specificity | BIF1 |
Clone | 30A882.1.1 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 kappa |
Format | Protein G purified |
Size | 100 µg |
Concentration | 1.0 mg/mL |
Applications | Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Bif-1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-Bif-1 from Human based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Bif-1 from other sources has not been determined. Anti-Bif-1 Antibody detects human BIF. The Bcl-2 family consists of anti-apoptotic (or cell survival) genes, such as Bcl-2, Bcl-XL and pro-apoptotic (or cell death) genes including Bax and BAD. In addition to its anti-apoptotic effect, Bcl-2 also inhibits progression through the cell cycle. Functional interactions between family members as well as binding to other cellular proteins modulate their activities. Bcl-2 family members are important in normal tissue development, homeostasis, and disease states. Bcl-2 prevents cell death by forming heterodimers with Bax and Bad. Bax promotes cell death by forming homodimers, which can be blocked by forming heterodimers with Bcl-2 or BCL-XL. Recently, using yeast two-hybrid system Cuddeback have identified a cDNA encoding a 365 amino acid protein, which interacts physically with Bax protein and influences cell life and death. Bif-1 contains a Src homology 3 (SH3) domain in the C-terminus. It does not contain any of the conserved Bcl-2 homology (BH) domains of the Bcl-2 family proteins. Human Bif-1 protein shares 96% and 42% identity at the amino acids level with mouse and C. elegans, respectively. Overexpression of Bif-1 in transfected cell lines promotes Bax conformational change, caspase activation, and apoptotic cell death following growth factor withdrawal. Bif-1 RNA is abundantly expressed in heart, skeletal muscle, kidney, and placenta. Anti-BIF-1 antibody is ideal for investigators involved in cytokines and growth factor research and NFkappaB and signaling research. |
Immunogen | Bif-1 Antibody was produced in mice and was prepared by repeated immunizations at the c-terminus of the human recombinant protein Bif-1. |
Other Names | KIAA0491, Endophilin-B1, Bax-interacting factor 1, Bif-1, SH3 domain-containing GRB2-like protein B1 |
Gene, Accession # | SH3GLB1, Gene ID: 51100, NCBI: NP_001193580.1, UniProt: Q9Y371 |
Catalog # | 200-301-H61 |
Price | $525 |
Order / More Info | BIF1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |