Edit |   |
---|---|
Antigenic Specificity | TOLLIP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-TOLLIP Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with TOLLIP from other sources has not been determined. Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation. |
Immunogen | Anti-TOLLIP antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the internal region of human TOLLIP. |
Other Names | TOLLIP Antibody, IL-1RAcPIP, Toll-interacting protein |
Gene, Accession # | TOLLIP, Gene ID: 54472, NCBI: NP_001305441.1, UniProt: Q9H0E2 |
Catalog # | 600-401-FL7 |
Price | $475 |
Order / More Info | TOLLIP Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |