ABCA4 Rim Protein Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | ABCA4 Rim Protein |
| Clone | 3F4 |
| Host Species | Mouse |
| Reactive Species | human, mouse, bovine, Xenopus |
| Isotype | IgG |
| Format | Protein G purified |
| Size | 100 µL |
| Concentration | Titrated value sufficient to run approximately 10 mini blots. |
| Applications | ELISA, Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-ABCA4 antibody is directed against bovine ABCA4 Rim Protein. The antibody was Protein G purified from culture supernatant. Reactivity is expected against human, mouse and Xenopus. Cross-reactivity with ABCA4 from other sources has not been determined. ABCA4 antibody detects ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABCA4 is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration. Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3). Anti-ABCA4 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research. |
| Immunogen | Anti-ABCA4 antibody was produced by repeated immunizations with 220-kDa (full length) partially purified native bovine disc rim protein. |
| Other Names | Retinal-specific ATP-binding cassette transporter, ATP-binding cassette sub-family A member 4, RIM ABC transporter |
| Gene, Accession # | ABCA4, Gene ID: 11304, NCBI: NP_776646.1, UniProt: O35600 |
| Catalog # | 200-301-D05 |
| Price | $485 |
| Order / More Info | ABCA4 Rim Protein Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 32946783 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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