Edit |   |
---|---|
Antigenic Specificity | IRF3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-IRF3 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with IRF3 from other sources has not been determined. Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF3 is present in an inactive form in the cytoplasm of most cells. Following viral infection, IRF3 can be activated by IkB kinase-e and TANK-binding kinase 1 (TBK1), whereupon IRF3 translocates to the nucleus. IRF3 can also be activated by stimulation of toll-like receptor 3 (TLR3) by dsRNA. IRF3 exists as at least two distinct isoforms. |
Immunogen | Anti-IRF3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to 14 amino acids near the C-terminus of human IRF3. |
Other Names | IRF3 Antibody, Interferon regulatory factor 3, IRF-3 |
Gene, Accession # | IRF3, Gene ID: 3661, NCBI: NP_001562, UniProt: Q14653 |
Catalog # | 600-401-CA1 |
Price | $475 |
Order / More Info | IRF3 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |