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Product Name | A-803467 |
Description | A-803467 is a potent and selective blocker of the TTX-resistant NaV1.8 channel. A-803467 is a state dependent inhibitor with IC50 of 8 nM at depolarized membrane potential (-40 mV) and 80 nM at -100 mV. As an efficient inhibitor of TTX-resistant currents in DRG neurons, A-803467 was also effective as an analgesic in several rodent models of different pathological pain states1,2. A-803467 was used as a pharmacological tool to demonstrate the expression of NaV1.8 in the heart conduction system and its contribution to QRS interval in the mouse heart3. Synthetic. Purity >99% (HPLC). MW: 357.8 |
Size | 10 mg |
Concentration | 10 nM - 10 µM. |
Applications | n/a |
Other Names | n/a |
Gene, Accession, CAS # | CAS: 944261-79-4 |
Catalog # | A-105 |
Price | please inquire |
Order / More Info | A-803467 from ALOMONE LABS |
Product Specific References | n/a |
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