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Product Name | CAY10744 |
Description | A topoisomerase II-α poison; inhibits topoisomerase II-α by 78.9% at 20 µM; selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 µM; inhibits proliferation of HCT15, T47D, DU145, and HeLa cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 µM, respectively); induces apoptosis in T47D cells at 10 and 30 µM; reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer at 12 mg/kg per day |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | CAY 10744 IIα HCT 15 T47 D T-47D 47 DU 145 MDAMB231 MDAMB MB231 |
Gene, Accession, CAS # | CAS: 2375613-31-1 |
Catalog # | 29802-1 |
Price | $57.00 |
Order / More Info | CAY10744 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |