DPTIP (hydrochloride) from CAYMAN CHEMICAL COMPANY
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| Product Name | DPTIP (hydrochloride) |
| Description | An nSMase2 inhibitor (IC50 = 30 nM); selective for nSMase2 over ALP and acid sphingomyelinase (IC50s = >100 µM for both); reduces viral yield in Vero and HeLa cells infected with West Nile virus (EC50s = 0.26 and 2.81 µM, respectively) or Zika virus (EC50s = 1.56 and 1.84 µM, respectively); prevents serum deprivation-induced astrocyte activation in primary rat astrocytes at 10 µM; reduces IL-1β-induced extracellular vesicle release from astrocytes, decreases neutrophil infiltration to the brain, and reduces hepatic levels of Ccl2, Tnf-α, Il-6, and Il-1β in a GFAP-GFP mouse model of inflammation-induced brain injury at 10 mg/kg, |
| Size | 25 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 351353-48-5 nSM ase2 IL1β GFAPGFP CCmotif Cc l2 C cl2 Il6 Tnfα |
| Gene, Accession, CAS # | CAS: 2361799-64-4 |
| Catalog # | 41681-25 |
| Price | $347.00 |
| Order / More Info | DPTIP (hydrochloride) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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