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Product Name | ARN3236 |
Description | An inhibitor of SIK2 (IC50 = 50s = 21.63 and 6.63 nM, respectively); inhibits TNF-α secretion in RAW 264.7 cells (IC50 = ~2.5 µM) and reduces phosphorylation of CRTC3 and HDAC4 in macrophages at 3 µM; inhibits growth of 10 ovarian cancer cell lines (IC50s = 0.8-2.6 µM) and increases sensitivity of eight of them to paclitaxel; halts the cell cycle at the G2/M phase and induces apoptosis and tetraploidy in SKOV3 cells at 1 µM; has an additive effect on reducing tumor growth when used in combination with paclitaxel in an ovarian cancer mouse xenograft model at 60 mg/kg per day |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | ARN 3236 SIK 1 2 3 TNFα CRTC HDAC 4 SKOV |
Gene, Accession, CAS # | CAS: 1613710-01-2 |
Catalog # | 31457-5 |
Price | $193.00 |
Order / More Info | ARN3236 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |