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Product Name | EDO-S101 |
Description | An HDAC inhibitor and DNA alkylating agent; inhibits class I and II HDACs (IC50s = 9-107 nM for HDAC1-3, 6, 8, and 10); inhibits HDAC activity in rat PBMCs ex vivo by 90% after a single dose of 10 mg/kg; induces formation of DNA crosslinks and double-strand breaks in HL-60 cells; reduces growth of MM cell lines irrespective of p53 mutational status or established resistance to DNA alkylating agents (IC50s = 1.6-4.8 µM); induces MM cell death ex vivo in bone marrow samples isolated from patients with early- and late-stage MM; reduces tumor growth and prolongs survival in an MM1S end-stage mouse xenograft model when administered at a dose of 60 mg/kg per week; prolongs survival in a multidrug resistant Vk12653 mouse transplant model of refractory MM, |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | EDOS101 EDO-S-101 HDAC-1 2 HL60 MM-1S Vk-12653 HDAC1 HDAC2 HDAC3 HDAC6 HDAC8 HDAC10 |
Gene, Accession, CAS # | CAS: 1236199-60-2 |
Catalog # | 23328-5 |
Price | $356.00 |
Order / More Info | EDO-S101 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |